Pair Name	Ursolic acid, Cisplatin
Disease Info	[ICD-11: 2C77]	Cervical cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CCNE1	hsa898
	Down-regulation	Expression	CDH13	hsa1012
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	RELA	hsa5970
In Vitro Model	HeLa	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0030
	C-33 A	Human papillomavirus-independent cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_1094
	SiHa	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_0032
	ME-180	Human papillomavirus-related cervical squamous cell carcinoma	Homo sapiens (Human)	CVCL_1401
Result	The combination of UA with DDP could more effectively inhibit SiHa cells proliferation and facilitate cell apoptosis through suppressing NF-κB p65.

Pair Name	Ursolic acid, Cisplatin
Disease Info	[ICD-11: 2C73]	Ovarian cancer		Investigative
Biological Phenomena	Inhibition-->Cell proliferation
Gene Regulation	Down-regulation	Expression	ABCG2	hsa9429
	Down-regulation	Expression	HIF1A	hsa3091
In Vitro Model	SK-OV-3	Ovarian serous cystadenocarcinoma	Homo sapiens (Human)	CVCL_0532
Result	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1α and ABCG2.

Pair Name	Ursolic acid, Cisplatin
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Expression	GSTK1	hsa373156
	Down-regulation	Expression	GSTK1	hsa373156
	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	HMOX1	hsa3162
	Down-regulation	Expression	NFE2L2	hsa4780
	Down-regulation	Expression	NQO1	hsa1728
	Down-regulation	Expression	NQO1	hsa1728
In Vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens (Human)	CVCL_0027
Result	The results confirmed the sensibilization of UA on HepG2/DDP cells to cisplatin, which was possibly mediated via the Nrf2/antioxidant response element pathway.